Guitar Hero III Mobile is an adaption of the Guitar Hero series of rhythm video games to mobile phones. The game was developed by MachineWorks Northwest LLC and is published by Hands-On Mobile. Guitar Hero III Mobile was released on December 20, 2007 in North America for Verizon Wireless customers. The game was later released for BlackBerry devices on April 1, 2008.

In a similar manner to other Guitar Hero games, the player simulates playing the lead guitar of several rock music songs by hitting notes that correspond to the phone's keypad buttons as they scroll down the screen in time to the music. Fifteen songs, taken from previous Guitar Hero games, are available in the base game, while a new three song track pack has been released each month since January 2008. The game has been downloaded over one million times, and over 250,000 songs are played on the platform each month.

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